Reactome | SLC27A1 transports arachidonate across the ER membrane

SLC27A1 transports arachidonate across the ER membrane

Stable Identifier

R-HSA-428990

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, cytosol, endoplasmic reticulum membrane

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)

ReviewStatus

5/5

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SLC27A1 transports arachidonate across the ER membrane

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Cytosolic arachidonate (AA) released by phospholipases is transported across the ER membrane by SLC27A1, providing input for eicosanoid synthetic reactions in the endoplasmic reticulum lumen as well as the cytosol. Human SLC27A1 has not been characterized experimentally; its subcellular location (Garcia-Martinez et al. 2005) and transporter activity (Shaffer and Lodish 1994) are inferred from the properties of the homologous mouse protein.

Literature References

PubMed ID	Title	Journal	Year
6810878	How is the level of free arachidonic acid controlled in mammalian cells? Irvine, RF	Biochem J	1982
15897321	Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells Guitart, M, Montell, E, Busquets, S, Moore-Carrasco, R, Marotta, M, Gómez-Foix, AM, García-Martínez, C, Camps, M	Am J Physiol Cell Physiol	2005
7954810	Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein Lodish, HF, Schaffer, JE	Cell	1994