Reactome | DCC mediated attractive signaling

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DCC mediated attractive signaling Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:418884] Garapati, P V, 2009-04-27 09:35:50
crossReference	[DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
dbId	418885
displayName	DCC mediated attractive signaling
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-373752] Netrin-1 signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-373711] DCC interaction with Netrin-1 - Homo sapiens [Reaction:R-HSA-373707] Netrin-1 induced DCC clustering - Homo sapiens [Reaction:R-HSA-373720] FADK1 interaction with DCC - Homo sapiens [Reaction:R-HSA-418872] Phosphorylation of FADK1 - Homo sapiens [Reaction:R-HSA-418868] Recruitment of Src and Fyn to DCC:FADK1 - Homo sapiens [Reaction:R-HSA-374701] Phosphorylation of DCC by Fyn - Homo sapiens [Reaction:R-HSA-373716] DCC interacting NCK-1 - Homo sapiens [Reaction:R-HSA-418858] RhoGTPase GEF's recruited to DCC - Homo sapiens [Reaction:R-HSA-418850] Activation of Cdc42 - Homo sapiens [Reaction:R-HSA-418856] Activation of Rac1 - Homo sapiens [Reaction:R-HSA-418874] Recruitment and activation of N-WASP by Cdc42 - Homo sapiens [Reaction:R-HSA-418865] Recruitment of ABLIM to the plasma membrane - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:418682] Netrin signaling leading to directed growth cone steering [LiteratureReference:418706] Focal adhesion kinase in netrin-1 signaling [LiteratureReference:418672] The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1 [LiteratureReference:373498] The Netrin family of guidance factors: emphasis on Netrin-1 signalling [LiteratureReference:373541] Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas [LiteratureReference:373462] The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism [LiteratureReference:373982] Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance [LiteratureReference:9928277] Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation [LiteratureReference:9928285] Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	DCC mediated attractive signaling
orthologousEvent	[Pathway:R-CEL-418885] DCC mediated attractive signaling - Caenorhabditis elegans [Pathway:R-BTA-418885] DCC mediated attractive signaling - Bos taurus [Pathway:R-CFA-418885] DCC mediated attractive signaling - Canis familiaris [Pathway:R-RNO-418885] DCC mediated attractive signaling - Rattus norvegicus [Pathway:R-MMU-418885] DCC mediated attractive signaling - Mus musculus
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-418885
summation	[Summation:418735] The DCC family includes DCC and neogenin in vertebrates. DCC...
updateTrackers	[UpdateTracker:9928510] Update Tracker - [Pathway:418885] DCC mediated attractive signaling - v91:[add_removeLiteratureReference] [UpdateTracker:9779594] Update Tracker - [Pathway:418885] DCC mediated attractive signaling - v65:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9928510] Update Tracker - [Pathway:418885] DCC mediated attractive signaling - v91:[add_removeLiteratureReference] [UpdateTracker:9779594] Update Tracker - [Pathway:418885] DCC mediated attractive signaling - v65:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-373752] Netrin-1 signaling

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