Reactome | Netrin-1 signaling

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Netrin-1 signaling Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
created	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
dbId	373752
displayName	Netrin-1 signaling
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-422475] Axon guidance - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-418885] DCC mediated attractive signaling - Homo sapiens [Pathway:R-HSA-418886] Netrin mediated repulsion signals - Homo sapiens [Reaction:R-HSA-373715] DCC interaction with ROBO1 - Homo sapiens [Reaction:R-HSA-374665] DCC interaction with SIAH1 - Homo sapiens [Reaction:R-HSA-374667] DCC interaction with SIAH2 - Homo sapiens [Reaction:R-HSA-374662] Translocation of Ezrin to plasma membrane - Homo sapiens [Reaction:R-HSA-374664] Phosphorylation and activation of Ezrin - Homo sapiens [Reaction:R-HSA-374663] DCC interaction with Ezrin - Homo sapiens [Reaction:R-HSA-593685] Netrin-4 binds DCC/UNC5A - Homo sapiens [Reaction:R-HSA-374689] Neogenin binds Netrin-1 - Homo sapiens [Reaction:R-HSA-374692] Neogenin binds repulsive guidance molecules (RGDs) - Homo sapiens [Reaction:R-HSA-593672] Myosin-X binds DCC/Neogenin - Homo sapiens [Reaction:R-HSA-622357] PIKE-L interaction with UNC5B - Homo sapiens [Pathway:R-HSA-418890] Role of second messengers in netrin-1 signaling - Homo sapiens [Pathway:R-HSA-376172] DSCAM interactions - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:421714] Netrins and their receptors [LiteratureReference:513012] The Deleted in Colorectal Cancer netrin guidance system: a molecular strategy for neuronal navigation
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Netrin-1 signaling
orthologousEvent	[Pathway:R-CEL-373752] Netrin-1 signaling - Caenorhabditis elegans [Pathway:R-DME-373752] Netrin-1 signaling - Drosophila melanogaster [Pathway:R-GGA-373752] Netrin-1 signaling - Gallus gallus [Pathway:R-XTR-373752] Netrin-1 signaling - Xenopus tropicalis [Pathway:R-DRE-373752] Netrin-1 signaling - Danio rerio [Pathway:R-SSC-373752] Netrin-1 signaling - Sus scrofa [Pathway:R-BTA-373752] Netrin-1 signaling - Bos taurus [Pathway:R-CFA-373752] Netrin-1 signaling - Canis familiaris [Pathway:R-RNO-373752] Netrin-1 signaling - Rattus norvegicus [Pathway:R-MMU-373752] Netrin-1 signaling - Mus musculus
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-373752
summation	[Summation:375907] Netrins are secreted proteins that play a crucial role in ne...
updateTrackers	[UpdateTracker:9780691] Update Tracker - [Pathway:373752] Netrin-1 signaling - v62:[updateContainedRLE] [UpdateTracker:9787698] Update Tracker - [Pathway:373752] Netrin-1 signaling - v44:[updateIndirectRLE] [UpdateTracker:9864315] Update Tracker - [Pathway:373752] Netrin-1 signaling - v88:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9779345] Update Tracker - [Pathway:373752] Netrin-1 signaling - v65:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9783562] Update Tracker - [Pathway:373752] Netrin-1 signaling - v56:[updateIndirectRLE] [UpdateTracker:9781455] Update Tracker - [Pathway:373752] Netrin-1 signaling - v61:[addHasEvent]

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[Pathway:R-HSA-422475] Axon guidance

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