Reactome | Activation of Cdc42

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Activation of Cdc42 Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
catalystActivity	[CatalystActivity:418851] guanyl-nucleotide exchange factor activity of NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:418857] Garapati, P V, 2009-04-27 09:26:20
dbId	418850
displayName	Activation of Cdc42
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-418885] DCC mediated attractive signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-418874] Recruitment and activation of N-WASP by Cdc42 - Homo sapiens [Reaction:R-HSA-389788] Activation of PAKs by RAC1 and CDC42 - Homo sapiens [Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2 - Homo sapiens [Reaction:R-HSA-8981926] RAC1 and CDC42 activate PAK3 - Homo sapiens
input	[Complex:R-HSA-418830] CDC42:GDP [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-418829] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:418684] Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion [LiteratureReference:418672] The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activation of Cdc42
orthologousEvent	[Reaction:R-MMU-418850] Activation of Cdc42 - Mus musculus [Reaction:R-CEL-418850] Activation of Cdc42 - Caenorhabditis elegans [Reaction:R-BTA-418850] Activation of Cdc42 - Bos taurus [Reaction:R-CFA-418850] Activation of Cdc42 - Canis familiaris [Reaction:R-RNO-418850] Activation of Cdc42 - Rattus norvegicus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-418820] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-418858] RhoGTPase GEF's recruited to DCC - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-418850
summation	[Summation:418711] RhoGEF complexed with Netrin-1-DCC induces guanine nucleotid...

Referrals

(precedingEvent)	[Reaction:R-HSA-418874] Recruitment and activation of N-WASP by Cdc42 [Reaction:R-HSA-389788] Activation of PAKs by RAC1 and CDC42 [Reaction:R-HSA-8981931] RAC1 and CDC42 activate PAK2 [Reaction:R-HSA-8981926] RAC1 and CDC42 activate PAK3
(hasEvent)	[Pathway:R-HSA-418885] DCC mediated attractive signaling

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