Reactome | RhoGTPase GEF's recruited to DCC

Schema > Reaction > Entries

RhoGTPase GEF's recruited to DCC Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:418857] Garapati, P V, 2009-04-27 09:26:20
dbId	418858
displayName	RhoGTPase GEF's recruited to DCC
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-418885] DCC mediated attractive signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-418850] Activation of Cdc42 - Homo sapiens [Reaction:R-HSA-418856] Activation of Rac1 - Homo sapiens
input	[DefinedSet:R-HSA-418807] DOCK1,TRIO [cytosol] [Complex:R-HSA-373663] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:418679] Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling [LiteratureReference:418722] Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance [LiteratureReference:418684] Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion [LiteratureReference:373462] The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism [LiteratureReference:418672] The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RhoGTPase GEF's recruited to DCC
orthologousEvent	[Reaction:R-MMU-418858] RhoGTPase GEF's recruited to DCC - Mus musculus [Reaction:R-CEL-418858] RhoGTPase GEF's recruited to DCC - Caenorhabditis elegans [Reaction:R-BTA-418858] RhoGTPase GEF's recruited to DCC - Bos taurus [Reaction:R-CFA-418858] RhoGTPase GEF's recruited to DCC - Canis familiaris [Reaction:R-RNO-418858] RhoGTPase GEF's recruited to DCC - Rattus norvegicus
output	[Complex:R-HSA-418829] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]
precedingEvent	[Reaction:R-HSA-373716] DCC interacting NCK-1 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-418858
summation	[Summation:418725] When Netrin-1 binds to the DCC-NCK1 complex, a conformationa...

Referrals

(hasEvent)	[Pathway:R-HSA-418885] DCC mediated attractive signaling
(precedingEvent)	[Reaction:R-HSA-418850] Activation of Cdc42 [Reaction:R-HSA-418856] Activation of Rac1