Reactome | Sema4D mediated inhibition of cell attachment and migration

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Sema4D mediated inhibition of cell attachment and migration Show undefined attributes

authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:416590] Garapati, P V, 2009-03-30 15:26:31
dbId	416550
displayName	Sema4D mediated inhibition of cell attachment and migration
edited	[InstanceEdit:399769] Garapati, P V, 2009-03-23 10:00:38
eventOf	[Pathway:R-HSA-400685] Sema4D in semaphorin signaling - Homo sapiens
figure	[Figure:9658521] /figures/static/R-HSA-416550.svg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-419646] SEMA4D interacts with Plexin-B1:Met - Homo sapiens [Reaction:R-HSA-400682] Active Rac1 interacts with Plexin-B1:Sema4D - Homo sapiens [Reaction:R-HSA-400677] Rnd1 interacts with Plexin-B1:Sema4D - Homo sapiens [Reaction:R-HSA-416546] Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity - Homo sapiens [Reaction:R-HSA-416562] p190RhoGAP binds Plexin-B1 - Homo sapiens [Reaction:R-HSA-416559] Inactivation of Rho-GTP by p190RhoGAP - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-12-18
literatureReference	[LiteratureReference:400681] Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D [LiteratureReference:399751] Semaphorin signaling: progress made and promises ahead [LiteratureReference:416545] Semaphorins command cells to move
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Sema4D mediated inhibition of cell attachment and migration
orthologousEvent	[Pathway:R-GGA-416550] Sema4D mediated inhibition of cell attachment and migration - Gallus gallus [Pathway:R-XTR-416550] Sema4D mediated inhibition of cell attachment and migration - Xenopus tropicalis [Pathway:R-DRE-416550] Sema4D mediated inhibition of cell attachment and migration - Danio rerio [Pathway:R-SSC-416550] Sema4D mediated inhibition of cell attachment and migration - Sus scrofa [Pathway:R-BTA-416550] Sema4D mediated inhibition of cell attachment and migration - Bos taurus [Pathway:R-CFA-416550] Sema4D mediated inhibition of cell attachment and migration - Canis familiaris [Pathway:R-RNO-416550] Sema4D mediated inhibition of cell attachment and migration - Rattus norvegicus [Pathway:R-MMU-416550] Sema4D mediated inhibition of cell attachment and migration - Mus musculus
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-416550
summation	[Summation:416549] Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, ...
updateTrackers	[UpdateTracker:9780363] Update Tracker - [Pathway:416550] Sema4D mediated inhibition of cell attachment and migration - v63:[updateContainedRLE] [UpdateTracker:9790966] Update Tracker - [Pathway:416550] Sema4D mediated inhibition of cell attachment and migration - v32:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9780363] Update Tracker - [Pathway:416550] Sema4D mediated inhibition of cell attachment and migration - v63:[updateContainedRLE] [UpdateTracker:9790966] Update Tracker - [Pathway:416550] Sema4D mediated inhibition of cell attachment and migration - v32:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-400685] Sema4D in semaphorin signaling