Reactome | Rnd1 interacts with Plexin-B1:Sema4D

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Rnd1 interacts with Plexin-B1:Sema4D Show undefined attributes

authored	[InstanceEdit:399743] Garapati, P V, 2009-03-23 09:59:28
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:400684] Garapati, P V, 2009-03-24 17:46:37
dbId	400677
displayName	Rnd1 interacts with Plexin-B1:Sema4D
edited	[InstanceEdit:399760] Garapati, P V, 2009-03-23 10:00:07
eventOf	[Pathway:R-HSA-416550] Sema4D mediated inhibition of cell attachment and migration - Homo sapiens
followingEvent	[Reaction:R-HSA-416562] p190RhoGAP binds Plexin-B1 - Homo sapiens [Reaction:R-HSA-416546] Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity - Homo sapiens
input	[Complex:R-HSA-421104] RND1:GTP [plasma membrane] [Complex:R-HSA-419621] SEMA4D:MET:p-Y-PLXNB1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:416578] Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Rnd1 interacts with Plexin-B1:Sema4D
orthologousEvent	[Reaction:R-XTR-400677] Rnd1 interacts with Plexin-B1:Sema4D - Xenopus tropicalis [Reaction:R-DRE-400677] Rnd1 interacts with Plexin-B1:Sema4D - Danio rerio [Reaction:R-SSC-400677] Rnd1 interacts with Plexin-B1:Sema4D - Sus scrofa [Reaction:R-BTA-400677] Rnd1 interacts with Plexin-B1:Sema4D - Bos taurus [Reaction:R-CFA-400677] Rnd1 interacts with Plexin-B1:Sema4D - Canis familiaris [Reaction:R-RNO-400677] Rnd1 interacts with Plexin-B1:Sema4D - Rattus norvegicus [Reaction:R-MMU-400677] Rnd1 interacts with Plexin-B1:Sema4D - Mus musculus
output	[Complex:R-HSA-416587] SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-400682] Active Rac1 interacts with Plexin-B1:Sema4D - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434621] Kumanogoh, A, Kikutani, H, 2009-09-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-400677
summation	[Summation:416563] Rnd1 is constitutively active and stably associates with Ple...
updateTrackers	[UpdateTracker:9791201] Update Tracker - [Reaction:400677] Rnd1 interacts with Plexin-B1:Sema4D - v32:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9791201] Update Tracker - [Reaction:400677] Rnd1 interacts with Plexin-B1:Sema4D - v32:[add_removeInput]
(precedingEvent)	[Reaction:R-HSA-416562] p190RhoGAP binds Plexin-B1 [Reaction:R-HSA-416546] Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
(hasEvent)	[Pathway:R-HSA-416550] Sema4D mediated inhibition of cell attachment and migration