Sema4D mediated inhibition of cell attachment and migration

Stable Identifier
R-HSA-416550
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.

Literature References
PubMed ID Title Journal Year
14770294 Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D

Kumanogoh, A, Kikutani, H

Cell Mol Life Sci 2004
16314868 Semaphorins command cells to move

Guan, KL, Aurandt, J, Kruger, RP

Nat Rev Mol Cell Biol 2005
18374575 Semaphorin signaling: progress made and promises ahead

Zhou, Y, Pasterkamp, RJ, Gunput, RA

Trends Biochem Sci 2008
Participants
Participates
Orthologous Events
Cross References
GlyCosmos
Authored
Reviewed
Created
Cite Us!