Reactome | Sema4D mediated inhibition of cell attachment and migration

Sema4D mediated inhibition of cell attachment and migration

Stable Identifier

R-HSA-416550

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

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Sema4D mediated inhibition of cell attachment and migration

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Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.

Literature References

PubMed ID	Title	Journal	Year
16314868	Semaphorins command cells to move Kruger, RP, Aurandt, J, Guan, KL	Nat Rev Mol Cell Biol	2005
14770294	Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D Kumanogoh, A, Kikutani, H	Cell Mol Life Sci	2004
18374575	Semaphorin signaling: progress made and promises ahead Zhou, Y, Gunput, RA, Pasterkamp, RJ	Trends Biochem Sci	2008