Reactome | Sema4D mediated inhibition of cell attachment and migration

Sema4D mediated inhibition of cell attachment and migration

Stable Identifier

R-HSA-416550

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Sema4D mediated inhibition of cell attachment and migration

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Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.

Literature References

PubMed ID	Title	Journal	Year
14770294	Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D Kumanogoh, A, Kikutani, H	Cell Mol Life Sci	2004
16314868	Semaphorins command cells to move Guan, KL, Aurandt, J, Kruger, RP	Nat Rev Mol Cell Biol	2005
18374575	Semaphorin signaling: progress made and promises ahead Zhou, Y, Pasterkamp, RJ, Gunput, RA	Trends Biochem Sci	2008