Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, ...

created [InstanceEdit:416590] Garapati, P V, 2009-03-30 15:26:31
dbId 416549
displayName Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, ...
literatureReference
modified [InstanceEdit:422114] Garapati, P V, 2009-05-26 09:11:17
schemaClass Summation
text Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.
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