Reactome | Sema4D mediated inhibition of cell attachment and migration

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Sema4D mediated inhibition of cell attachment and migration Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100195
displayName	Sema4D mediated inhibition of cell attachment and migration
eventOf	[Pathway:R-MMU-400685] Sema4D in semaphorin signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-419646] SEMA4D interacts with Plexin-B1:Met - Mus musculus [Reaction:R-MMU-400682] Active Rac1 interacts with Plexin-B1:Sema4D - Mus musculus [Reaction:R-MMU-400677] Rnd1 interacts with Plexin-B1:Sema4D - Mus musculus [Reaction:R-MMU-416546] Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity - Mus musculus [Reaction:R-MMU-416562] p190RhoGAP binds Plexin-B1 - Mus musculus [Reaction:R-MMU-416559] Inactivation of Rho-GTP by p190RhoGAP - Mus musculus
inferredFrom	[Pathway:R-HSA-416550] Sema4D mediated inhibition of cell attachment and migration - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sema4D mediated inhibition of cell attachment and migration
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-416550
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-400685] Sema4D in semaphorin signaling
(inferredTo)	[Pathway:R-HSA-416550] Sema4D mediated inhibition of cell attachment and migration

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