Reactome | Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

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Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins Show undefined attributes

authored	[InstanceEdit:422245] May, B, 2009-05-27 03:41:50
catalystActivity	[CatalystActivity:9857127] guanyl-nucleotide exchange factor activity of ADRA2A,C:ADR,NAd [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:400084] May, B, 2009-03-24 01:57:51
dbId	400092
displayName	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
edited	[InstanceEdit:422243] May, B, 2009-05-27 03:41:18
eventOf	[Pathway:R-HSA-400042] Adrenaline,noradrenaline inhibits insulin secretion - Homo sapiens
followingEvent	[Reaction:R-HSA-400037] Gi,Go Heterotrimeric G-protein complex dissociates - Homo sapiens
input	[Complex:R-HSA-400088] G-alpha(i,o):GDP:G beta:G gamma [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:446421] Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors [LiteratureReference:446425] Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells [LiteratureReference:446428] Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors [LiteratureReference:446429] Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains [LiteratureReference:428058] Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells [LiteratureReference:446427] Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms [LiteratureReference:446424] Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles [LiteratureReference:400054] Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [LiteratureReference:400089] Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400059] Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice [LiteratureReference:400072] Mechanisms of inhibition of insulin release
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
orthologousEvent	[Reaction:R-CEL-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Caenorhabditis elegans [Reaction:R-XTR-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Xenopus tropicalis [Reaction:R-DRE-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Danio rerio [Reaction:R-BTA-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Bos taurus [Reaction:R-RNO-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Rattus norvegicus [Reaction:R-MMU-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Mus musculus
output	[Complex:R-HSA-400031] G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-HSA-400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422547] D'Eustachio, P, 2009-06-02 00:48:17 [InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-400092
summation	[Summation:400087] In the pancreatic beta cell, alpha2 adrenergic receptors are...
updateTrackers	[UpdateTracker:9790728] Update Tracker - [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - v33:[addRegulator] [UpdateTracker:9791374] Update Tracker - [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - v31:[add_removeLiteratureReference] [UpdateTracker:9863952] Update Tracker - [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - v88:[addCatalystActivity, removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9790728] Update Tracker - [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - v33:[addRegulator] [UpdateTracker:9791374] Update Tracker - [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - v31:[add_removeLiteratureReference] [UpdateTracker:9863952] Update Tracker - [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - v88:[addCatalystActivity, removeRegulator]
(hasEvent)	[Pathway:R-HSA-400042] Adrenaline,noradrenaline inhibits insulin secretion
(precedingEvent)	[Reaction:R-HSA-400037] Gi,Go Heterotrimeric G-protein complex dissociates

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