Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

Stable Identifier
R-HSA-400092
Type
Reaction [transition]
Species
Homo sapiens
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In the pancreatic beta cell, alpha2 adrenergic receptors are coupled to Gi and Go heterotrimeric G-proteins. Binding of adrenaline or noradrenaline by the alpha2 adrenergic receptor acts through protein-protein interaction to stimulate the Gi alpha subunit or Go alpha subunit in heterotrimeric G-protein complexes to exchange GDP for GTP. The particular G alpha subunits have been identified in mice as Gi alpha1, Gi alpha 2, and Go alpha2.

Literature References
PubMed ID Title Journal Year
16352729 Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

Nobles, M, Benians, A, Tinker, A

Proc Natl Acad Sci U S A 2005
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Lang, J, Nishimoto, I, Okamoto, T, Regazzi, R, Kiraly, C, Weller, U, Wollheim, CB

EMBO J 1995
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
1849000 Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles

Kurose, H, Regan, JW, Caron, MG, Lefkowitz, RJ

Biochemistry 1991
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Peterhoff, M, Sieg, A, Brede, M, Chao, CM, Hein, L, Ullrich, S

Eur J Endocrinol 2003
1645720 Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms

Dalman, HM, Neubig, RR

J Biol Chem 1991
8099279 Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells

Remaury, A, Larrouy, D, Daviaud, D, Rouot, B, Paris, H

Biochem J 1993
8662784 Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains

Eason, MG, Liggett, SB

J Biol Chem 1996
9760042 Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors

Peltonen, JM, Pihlavisto, M, Scheinin, M

Eur J Pharmacol 1998
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
16371464 Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors

Gibson, SK, Gilman, AG

Proc Natl Acad Sci U S A 2006
18162464 Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel

Zhao, Y, Fang, Q, Straub, SG, Sharp, GW

J Biol Chem 2008
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