Reactome | Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

Stable Identifier

R-HSA-400092

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

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In the pancreatic beta cell, alpha2 adrenergic receptors are coupled to Gi and Go heterotrimeric G-proteins. Binding of adrenaline or noradrenaline by the alpha2 adrenergic receptor acts through protein-protein interaction to stimulate the Gi alpha subunit or Go alpha subunit in heterotrimeric G-protein complexes to exchange GDP for GTP. The particular G alpha subunits have been identified in mice as Gi alpha1, Gi alpha 2, and Go alpha2.

Literature References

PubMed ID	Title	Journal	Year
7641683	Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I	EMBO J	1995
16352729	Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells Tinker, A, Nobles, M, Benians, A	Proc Natl Acad Sci U S A	2005
8997178	Mechanisms of inhibition of insulin release Sharp, GW	Am J Physiol	1996
1849000	Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles Regan, JW, Caron, MG, Lefkowitz, RJ, Kurose, H	Biochemistry	1991
14514350	Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S	Eur J Endocrinol	2003
1645720	Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms Neubig, RR, Dalman, HM	J Biol Chem	1991
8099279	Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells Rouot, B, Paris, H, Remaury, A, Daviaud, D, Larrouy, D	Biochem J	1993
8662784	Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains Liggett, SB, Eason, MG	J Biol Chem	1996
9760042	Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors Scheinin, M, Pihlavisto, M, Peltonen, JM	Eur J Pharmacol	1998
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Ahren, B, Winzell, MS	Pharmacol Ther	2007
16371464	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors Gilman, AG, Gibson, SK	Proc Natl Acad Sci U S A	2006
18162464	Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel Straub, SG, Fang, Q, Sharp, GW, Zhao, Y	J Biol Chem	2008