Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

Stable Identifier
Reaction [transition]
Homo sapiens
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In the pancreatic beta cell, alpha2 adrenergic receptors are coupled to Gi and Go heterotrimeric G-proteins. Binding of adrenaline or noradrenaline by the alpha2 adrenergic receptor acts through protein-protein interaction to stimulate the Gi alpha subunit or Go alpha subunit in heterotrimeric G-protein complexes to exchange GDP for GTP. The particular G alpha subunits have been identified in mice as Gi alpha1, Gi alpha 2, and Go alpha2.
Literature References
PubMed ID Title Journal Year
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I

EMBO J 1995
16352729 Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

Tinker, A, Nobles, M, Benians, A

Proc Natl Acad Sci U S A 2005
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
1849000 Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles

Regan, JW, Caron, MG, Lefkowitz, RJ, Kurose, H

Biochemistry 1991
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S

Eur J Endocrinol 2003
1645720 Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms

Neubig, RR, Dalman, HM

J Biol Chem 1991
8099279 Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells

Rouot, B, Paris, H, Remaury, A, Daviaud, D, Larrouy, D

Biochem J 1993
8662784 Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains

Liggett, SB, Eason, MG

J Biol Chem 1996
9760042 Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors

Scheinin, M, Pihlavisto, M, Peltonen, JM

Eur J Pharmacol 1998
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
16371464 Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors

Gilman, AG, Gibson, SK

Proc Natl Acad Sci U S A 2006
18162464 Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel

Straub, SG, Fang, Q, Sharp, GW, Zhao, Y

J Biol Chem 2008
Catalyst Activity

guanyl-nucleotide exchange factor activity of ADRA2A,C:ADR,NAd [plasma membrane]

Orthologous Events
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