Reactome | Adrenaline,noradrenaline inhibits insulin secretion

Schema > Pathway > Entries

Adrenaline,noradrenaline inhibits insulin secretion Show undefined attributes

authored	[InstanceEdit:422245] May, B, 2009-05-27 03:41:50
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:400084] May, B, 2009-03-24 01:57:51
crossReference	[DatabaseIdentifier:12819463] BioModels Database:BIOMD0000000088
dbId	400042
displayName	Adrenaline,noradrenaline inhibits insulin secretion
doi	10.3180/R-HSA-400042.6
edited	[InstanceEdit:422245] May, B, 2009-05-27 03:41:50
eventOf	[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25918] negative regulation of insulin secretion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline - Homo sapiens [Reaction:R-HSA-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Homo sapiens [Reaction:R-HSA-400037] Gi,Go Heterotrimeric G-protein complex dissociates - Homo sapiens [BlackBoxEvent:R-HSA-400046] L-type Calcium Channels close in pancreatic beta cells - Homo sapiens [BlackBoxEvent:R-HSA-400063] Low conductance potassium channels in pancreatic beta cells open in response to epinephrine - Homo sapiens [Reaction:R-HSA-400097] G-beta:G-gamma inhibits Adenylate cyclase - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:400054] Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [LiteratureReference:400089] Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400059] Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice [LiteratureReference:400072] Mechanisms of inhibition of insulin release [LiteratureReference:400064] Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2 [LiteratureReference:400096] Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteins
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Adrenaline,noradrenaline inhibits insulin secretion
orthologousEvent	[Pathway:R-CEL-400042] Adrenaline,noradrenaline inhibits insulin secretion - Caenorhabditis elegans [Pathway:R-DME-400042] Adrenaline,noradrenaline inhibits insulin secretion - Drosophila melanogaster [Pathway:R-GGA-400042] Adrenaline,noradrenaline inhibits insulin secretion - Gallus gallus [Pathway:R-XTR-400042] Adrenaline,noradrenaline inhibits insulin secretion - Xenopus tropicalis [Pathway:R-DRE-400042] Adrenaline,noradrenaline inhibits insulin secretion - Danio rerio [Pathway:R-SSC-400042] Adrenaline,noradrenaline inhibits insulin secretion - Sus scrofa [Pathway:R-BTA-400042] Adrenaline,noradrenaline inhibits insulin secretion - Bos taurus [Pathway:R-CFA-400042] Adrenaline,noradrenaline inhibits insulin secretion - Canis familiaris [Pathway:R-RNO-400042] Adrenaline,noradrenaline inhibits insulin secretion - Rattus norvegicus [Pathway:R-MMU-400042] Adrenaline,noradrenaline inhibits insulin secretion - Mus musculus
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422547] D'Eustachio, P, 2009-06-02 00:48:17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-400042
summation	[Summation:400080] The catecholamines adrenaline (epinephrine) and noradrenalin...
updateTrackers	[UpdateTracker:9791245] Update Tracker - [Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion - v31:[removeLiteratureReference, updateContainedRLE] [UpdateTracker:9864055] Update Tracker - [Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion - v88:[updateContainedRLE] [UpdateTracker:9790724] Update Tracker - [Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion - v33:[removeHasEvent, updateContainedRLE] [UpdateTracker:9781568] Update Tracker - [Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion - v60:[updateContainedRLE]

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-422356] Regulation of insulin secretion

Cite Us!