Reactome | Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

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Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins Show undefined attributes

catalystActivity	[CatalystActivity:10935491] guanyl-nucleotide exchange factor activity of ADRA2A,C:ADR,NAd [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10935493
displayName	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
eventOf	[Pathway:R-CEL-400042] Adrenaline,noradrenaline inhibits insulin secretion - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-400037] Gi,Go Heterotrimeric G-protein complex dissociates - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Homo sapiens
input	[Complex:R-CEL-400088] G-alpha(i,o):GDP:G beta:G gamma [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
output	[Complex:R-CEL-400031] G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-CEL-400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-400092
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-400042] Adrenaline,noradrenaline inhibits insulin secretion
(precedingEvent)	[Reaction:R-CEL-400037] Gi,Go Heterotrimeric G-protein complex dissociates
(inferredTo)	[Reaction:R-HSA-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins

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