Reactome | Diacylgycerol activates Protein kinase C, alpha type

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Diacylgycerol activates Protein kinase C, alpha type Show undefined attributes

authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity	[CatalystActivity:9860667] diacylglycerol binding activity of PRKCA [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
dbId	400015
displayName	Diacylgycerol activates Protein kinase C, alpha type
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
eventOf	[Pathway:R-HSA-2179392] EGFR Transactivation by Gastrin - Homo sapiens [Pathway:R-HSA-399997] Acetylcholine regulates insulin secretion - Homo sapiens
followingEvent	[Reaction:R-HSA-399978] Protein kinase C, alpha type phosphorylates MARCKS - Homo sapiens [BlackBoxEvent:R-HSA-2179413] Activated PKC-alpha activate MMP3 - Homo sapiens
input	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [EntityWithAccessionedSequence:R-HSA-58196] PRKCA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function [LiteratureReference:9029472] Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Diacylgycerol activates Protein kinase C, alpha type
orthologousEvent	[Reaction:R-SCE-400015] Diacylgycerol activates Protein kinase C, alpha type - Saccharomyces cerevisiae [Reaction:R-SPO-400015] Diacylgycerol activates Protein kinase C, alpha type - Schizosaccharomyces pombe [Reaction:R-DDI-400015] Diacylgycerol activates Protein kinase C, alpha type - Dictyostelium discoideum [Reaction:R-CEL-400015] Diacylgycerol activates Protein kinase C, alpha type - Caenorhabditis elegans [Reaction:R-DME-400015] Diacylgycerol activates Protein kinase C, alpha type - Drosophila melanogaster [Reaction:R-DRE-400015] Diacylgycerol activates Protein kinase C, alpha type - Danio rerio [Reaction:R-SSC-400015] Diacylgycerol activates Protein kinase C, alpha type - Sus scrofa [Reaction:R-CFA-400015] Diacylgycerol activates Protein kinase C, alpha type - Canis familiaris [Reaction:R-RNO-400015] Diacylgycerol activates Protein kinase C, alpha type - Rattus norvegicus [Reaction:R-MMU-400015] Diacylgycerol activates Protein kinase C, alpha type - Mus musculus
output	[Complex:R-HSA-422275] Protein Kinase C, alpha type: DAG [plasma membrane]
precedingEvent	[Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-400015
summation	[Summation:400019] Diacylglycerol, produced by PLC beta-mediated PIP2 hydrolysi...
updateTrackers	[UpdateTracker:9779788] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v64:[addLiteratureReference] [UpdateTracker:9864287] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v88:[addCatalystActivity] [UpdateTracker:9788536] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v41:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779788] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v64:[addLiteratureReference] [UpdateTracker:9864287] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v88:[addCatalystActivity] [UpdateTracker:9788536] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v41:[modifyText]
(precedingEvent)	[Reaction:R-HSA-399978] Protein kinase C, alpha type phosphorylates MARCKS [BlackBoxEvent:R-HSA-2179413] Activated PKC-alpha activate MMP3
(hasEvent)	[Pathway:R-HSA-399997] Acetylcholine regulates insulin secretion [Pathway:R-HSA-2179392] EGFR Transactivation by Gastrin

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