Reactome | Acetylcholine regulates insulin secretion

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Acetylcholine regulates insulin secretion Show undefined attributes

authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
crossReference	[DatabaseIdentifier:12819463] BioModels Database:BIOMD0000000088
dbId	399997
displayName	Acetylcholine regulates insulin secretion
doi	10.3180/R-HSA-399997.5
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
eventOf	[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262055] positive regulation of insulin secretion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-400012] Acetylcholine binds Muscarinic Acetylcholine Receptor M3 - Homo sapiens [Reaction:R-HSA-399995] Muscarinic Acetylcholine Receptor M3 activates Gq - Homo sapiens [Reaction:R-HSA-400027] Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma - Homo sapiens [Reaction:R-HSA-400023] Gq alpha activates Phospholipase C beta - Homo sapiens [Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Homo sapiens [Reaction:R-HSA-400015] Diacylgycerol activates Protein kinase C, alpha type - Homo sapiens [Reaction:R-HSA-399978] Protein kinase C, alpha type phosphorylates MARCKS - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function [LiteratureReference:400006] G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Acetylcholine regulates insulin secretion
orthologousEvent	[Pathway:R-SCE-399997] Acetylcholine regulates insulin secretion - Saccharomyces cerevisiae [Pathway:R-SPO-399997] Acetylcholine regulates insulin secretion - Schizosaccharomyces pombe [Pathway:R-DDI-399997] Acetylcholine regulates insulin secretion - Dictyostelium discoideum [Pathway:R-CEL-399997] Acetylcholine regulates insulin secretion - Caenorhabditis elegans [Pathway:R-DME-399997] Acetylcholine regulates insulin secretion - Drosophila melanogaster [Pathway:R-GGA-399997] Acetylcholine regulates insulin secretion - Gallus gallus [Pathway:R-XTR-399997] Acetylcholine regulates insulin secretion - Xenopus tropicalis [Pathway:R-DRE-399997] Acetylcholine regulates insulin secretion - Danio rerio [Pathway:R-SSC-399997] Acetylcholine regulates insulin secretion - Sus scrofa [Pathway:R-BTA-399997] Acetylcholine regulates insulin secretion - Bos taurus [Pathway:R-CFA-399997] Acetylcholine regulates insulin secretion - Canis familiaris [Pathway:R-RNO-399997] Acetylcholine regulates insulin secretion - Rattus norvegicus [Pathway:R-MMU-399997] Acetylcholine regulates insulin secretion - Mus musculus
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-399997
summation	[Summation:399977] Acetylcholine released by parasympathetic nerve endings in t...
updateTrackers	[UpdateTracker:9864148] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v88:[updateContainedRLE] [UpdateTracker:9779926] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v64:[updateContainedRLE] [UpdateTracker:9788594] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v41:[updateContainedRLE] [UpdateTracker:9790690] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v33:[removeHasEvent, updateContainedRLE] [UpdateTracker:9791444] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v30:[updateContainedRLE] [UpdateTracker:9787995] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v44:[updateContainedRLE] [UpdateTracker:9791286] Update Tracker - [Pathway:399997] Acetylcholine regulates insulin secretion - v31:[updateContainedRLE]

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[Pathway:R-HSA-422356] Regulation of insulin secretion

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