Reactome | Protein kinase C, alpha type phosphorylates MARCKS

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Protein kinase C, alpha type phosphorylates MARCKS Show undefined attributes

authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity	[CatalystActivity:400010] protein serine/threonine kinase activity of Protein Kinase C, alpha type: DAG [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
dbId	399978
displayName	Protein kinase C, alpha type phosphorylates MARCKS
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
eventOf	[Pathway:R-HSA-399997] Acetylcholine regulates insulin secretion - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-399985] MARCKS [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:399974] Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets [LiteratureReference:445879] Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate [LiteratureReference:445885] The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries [LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function [LiteratureReference:422288] Global, in vivo, and site-specific phosphorylation dynamics in signaling networks [LiteratureReference:445881] Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Protein kinase C, alpha type phosphorylates MARCKS
orthologousEvent	[Reaction:R-DRE-399978] Protein kinase C, alpha type phosphorylates MARCKS - Danio rerio [Reaction:R-SSC-399978] Protein kinase C, alpha type phosphorylates MARCKS - Sus scrofa [Reaction:R-CFA-399978] Protein kinase C, alpha type phosphorylates MARCKS - Canis familiaris [Reaction:R-RNO-399978] Protein kinase C, alpha type phosphorylates MARCKS - Rattus norvegicus [Reaction:R-MMU-399978] Protein kinase C, alpha type phosphorylates MARCKS - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-399989] p-4S-MARCKS [plasma membrane]
precedingEvent	[Reaction:R-HSA-400015] Diacylgycerol activates Protein kinase C, alpha type - Homo sapiens
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-399978
summation	[Summation:400029] One of the known targets of PKC-alpha is the Myristoylated A...
updateTrackers	[UpdateTracker:9791288] Update Tracker - [Reaction:399978] Protein kinase C, alpha type phosphorylates MARCKS - v31:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9791288] Update Tracker - [Reaction:399978] Protein kinase C, alpha type phosphorylates MARCKS - v31:[addLiteratureReference]
(hasEvent)	[Pathway:R-HSA-399997] Acetylcholine regulates insulin secretion

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