Reactome | PRKCA [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PRKCA [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9839179] Keratinocyte PKCs [cytosol] - Homo sapiens
catalystActivities	[CatalystActivity:418860] calcium,diacylglycerol-dependent serine/threonine kinase activity of PRKCA [cytosol] [CatalystActivity:9860667] diacylglycerol binding activity of PRKCA [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-422275] Protein Kinase C, alpha type: DAG [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-400015] Diacylgycerol activates Protein kinase C, alpha type - Homo sapiens [Reaction:R-HSA-1433508] PKC alpha interacts with and phosphorylates KIT - Homo sapiens
dbId	58196
displayName	PRKCA [cytosol]
endCoordinate	672
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-58196] PRKCA [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-58196] PRKCA [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-58196] PRKCA [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-SSC-58196] PRKCA [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-58196] PRKCA [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-DME-58196] PRKCA [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-58196-2] PRKCA [cytosol] - Drosophila melanogaster [DefinedSet:R-DME-58196-3] Homologues of PRKCA [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-58196] PRKCA [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-58196] PRKCA [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-58196-2] PRKCA [cytosol] - Dictyostelium discoideum [DefinedSet:R-DDI-58196-3] Homologues of PRKCA [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-58196] PRKCA [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SPO-58196-2] PRKCA [cytosol] - Schizosaccharomyces pombe [DefinedSet:R-SPO-58196-3] Homologues of PRKCA [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-58196] PRKCA [cytosol] - Saccharomyces cerevisiae
literatureReference	[LiteratureReference:9029469] Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells
maxDepth	1
memberOf	[DefinedSet:R-HSA-114528] Protein Kinase C, conventional [cytosol] - Homo sapiens [DefinedSet:R-HSA-8855913] RET interactors [cytosol] - Homo sapiens
modified	[InstanceEdit:9029474] May, Bruce, 2017-11-19
name	PRKCA Protein kinase C, alpha type PKC-alpha PKC-A
referenceEntity	[ReferenceGeneProduct:uniprot:P17252] UniProt:P17252 PRKCA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-58196
startCoordinate	2
updateTrackers	[UpdateTracker:9898914] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v64:[addLiteratureReference] [UpdateTracker:9868305] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v30:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9887248] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v45:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9898914] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v64:[addLiteratureReference] [UpdateTracker:9868305] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v30:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9887248] Update Tracker - [EntityWithAccessionedSequence:58196] PRKCA [cytosol] - v45:[addName]
(activeUnit)	[CatalystActivity:400010] protein serine/threonine kinase activity of Protein Kinase C, alpha type: DAG [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-114528] Protein Kinase C, conventional [cytosol] [DefinedSet:R-HSA-8855913] RET interactors [cytosol] [DefinedSet:R-HSA-5218761] PKCA,PKCB,PKCD,PKCZ [cytosol] [DefinedSet:R-HSA-112001] Protein kinase C (alpha, gamma, delta) [cytosol]
(hasCandidate)	[CandidateSet:R-HSA-9839179] Keratinocyte PKCs [cytosol]
(input)	[Reaction:R-HSA-1433508] PKC alpha interacts with and phosphorylates KIT [Reaction:R-HSA-400015] Diacylgycerol activates Protein kinase C, alpha type
(physicalEntity)	[CatalystActivity:418860] calcium,diacylglycerol-dependent serine/threonine kinase activity of PRKCA [cytosol] [CatalystActivity:9860667] diacylglycerol binding activity of PRKCA [cytosol]
(hasComponent)	[Complex:R-HSA-422275] Protein Kinase C, alpha type: DAG [plasma membrane] [Complex:R-HSA-1433473] p-KIT (S741,746):PKC alpha [plasma membrane]

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