Diacylgycerol activates Protein kinase C, alpha type

Stable Identifier
R-HSA-400015
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Diacylgycerol activates Protein kinase C, alpha type
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Diacylglycerol, produced by PLC beta-mediated PIP2 hydrolysis in G alpha (q) signalling, remains in the plasma membrane and binds Protein Kinase C alpha (PKC-alpha), causing PKC-alpha to translocate from the cytosol to the plasma membrane. PKC-alpha is thereby activated and phosphorylates target proteins.
Literature References
PubMed ID Title Journal Year
11997388 Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP

Tanimura, A, Nezu, A, Morita, T, Hashimoto, N, Tojyo, Y

J. Biol. Chem. 2002
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

diacylglycerol binding activity of PRKCA [cytosol]

Physical Entity
PRKCA [cytosol] (Homo sapiens)
Activity
diacylglycerol binding (GO:0019992)
Orthologous Events
Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)
Diacylgycerol activates Protein kinase C, alpha type (Canis familiaris)
Diacylgycerol activates Protein kinase C, alpha type (Danio rerio)
Diacylgycerol activates Protein kinase C, alpha type (Dictyostelium discoideum)
Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)
Diacylgycerol activates Protein kinase C, alpha type (Mus musculus)
Diacylgycerol activates Protein kinase C, alpha type (Rattus norvegicus)
Diacylgycerol activates Protein kinase C, alpha type (Saccharomyces cerevisiae)
Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)
Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)
Authored
May, B  (2009-05-28)
Reviewed
Gillespie, ME  (2009-06-02)
Hill, DP  (2024-02-12)
Created
May, B  (2009-03-24)
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