Diacylgycerol activates Protein kinase C, alpha type

Stable Identifier
R-HSA-400015
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Diacylglycerol, produced by PLC beta-mediated PIP2 hydrolysis in G alpha (q) signalling, remains in the plasma membrane and binds Protein Kinase C alpha (PKC-alpha), causing PKC-alpha to translocate from the cytosol to the plasma membrane. PKC-alpha is thereby activated and phosphorylates target proteins.

Literature References
PubMed ID Title Journal Year
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
11997388 Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP

Tanimura, A, Nezu, A, Morita, T, Hashimoto, N, Tojyo, Y

J. Biol. Chem. 2002
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