Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
Show undefined attributes
Go to Details
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
dbId
114548
displayName
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
edited
[InstanceEdit:435388] Jupe, S, 2009-09-09
eventOf
[Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
followingEvent
[Reaction:R-HSA-114544] p115-RhoGEF activation of RHOA - Homo sapiens
[Reaction:R-HSA-419166] GEFs activate RhoA,B,C - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-114526] ARHGEF1 [cytosol]
[Complex:R-HSA-398056] G-protein alpha (13):GTP [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:140014] RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
[LiteratureReference:165196] The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
[LiteratureReference:8874416] Activation of p115-RhoGEF requires direct association of G?13 and the Dbl homology domain
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
orthologousEvent
[Reaction:R-CEL-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Caenorhabditis elegans
[Reaction:R-DME-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Drosophila melanogaster
[Reaction:R-GGA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Gallus gallus
[Reaction:R-SSC-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Sus scrofa
[Reaction:R-BTA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Bos taurus
[Reaction:R-CFA-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Canis familiaris
[Reaction:R-RNO-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Rattus norvegicus
[Reaction:R-MMU-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Mus musculus
output
[Complex:R-HSA-114527] G13-activated p115-RhoGEF [plasma membrane]
precedingEvent
[Reaction:R-HSA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Homo sapiens
[Reaction:R-HSA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Homo sapiens
[Reaction:R-HSA-428918] Dissociation of the TP:G13 complex - Homo sapiens
[Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates - Homo sapiens
releaseDate
2004-10-27
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-114548
summation
[Summation:178380] p115-RhoGEF is a potent GTPase activating protein (GAP) for ...
updateTrackers
[UpdateTracker:9782825] Update Tracker - [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - v58:[addLiteratureReference, modifyText]
[UpdateTracker:9791536] Update Tracker - [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - v29:[modifyText]
[UpdateTracker:9791652] Update Tracker - [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - v28:[addLiteratureReference, add_removeInput, modifyText, removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9782825] Update Tracker - [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - v58:[addLiteratureReference, modifyText]
[UpdateTracker:9791536] Update Tracker - [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - v29:[modifyText]
[UpdateTracker:9791652] Update Tracker - [Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - v28:[addLiteratureReference, add_removeInput, modifyText, removeOutput]
(hasEvent)
[Pathway:R-HSA-416482] G alpha (12/13) signalling events
(precedingEvent)
[Reaction:R-HSA-114544] p115-RhoGEF activation of RHOA
[Reaction:R-HSA-419166] GEFs activate RhoA,B,C
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text