Reactome | Thrombin-activated PARs:G12/13 (active) dissociate

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Thrombin-activated PARs:G12/13 (active) dissociate Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10935182
displayName	Thrombin-activated PARs:G12/13 (active) dissociate
eventOf	[Pathway:R-CEL-456926] Thrombin signalling through proteinase activated receptors (PARs) - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Caenorhabditis elegans [Reaction:R-CEL-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Caenorhabditis elegans [Reaction:R-CEL-398184] LARG activation by G alpha 12/13 - Caenorhabditis elegans [Reaction:R-CEL-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Homo sapiens
input	[Complex:R-CEL-397884] Thrombin activated PAR:G12/13 (active) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Thrombin-activated PARs:G12/13 (active) dissociate
output	[DefinedSet:R-CEL-418572] G-protein alpha (12/13):GTP [plasma membrane] 2 × [Complex:R-CEL-167434] G-protein beta-gamma complex [plasma membrane] [EntityWithAccessionedSequence:R-CEL-114532] gnrr-4 [plasma membrane]
precedingEvent	[Reaction:R-CEL-114552] Thrombin-activated PARs activate G12/13 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-397891
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-456926] Thrombin signalling through proteinase activated receptors (PARs)
(precedingEvent)	[Reaction:R-CEL-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP [Reaction:R-CEL-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Reaction:R-CEL-398184] LARG activation by G alpha 12/13 [Reaction:R-CEL-114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)
(inferredTo)	[Reaction:R-HSA-397891] Thrombin-activated PARs:G12/13 (active) dissociate