Reactome | G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP

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G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP Show undefined attributes

authored	[InstanceEdit:418569] Jupe, S, 2009-04-24 08:15:10
catalystActivity	[CatalystActivity:418573] GTPase activity of G-protein alpha (12/13):GTP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:418571] Jupe, S, 2009-04-24 09:54:39
dbId	418574
displayName	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-416482] G alpha (12/13) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-751039] Inactive G alpha (12/13) reassociates with G beta:gamma - Homo sapiens
input	[DefinedSet:R-HSA-418572] G-protein alpha (12/13):GTP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:374843] Mechanism of GTP hydrolysis by G-protein alpha subunits
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP
orthologousEvent	[Reaction:R-DDI-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Dictyostelium discoideum [Reaction:R-CEL-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Caenorhabditis elegans [Reaction:R-DME-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Drosophila melanogaster [Reaction:R-GGA-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Gallus gallus [Reaction:R-XTR-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Xenopus tropicalis [Reaction:R-DRE-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Danio rerio [Reaction:R-SSC-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Sus scrofa [Reaction:R-BTA-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Bos taurus [Reaction:R-CFA-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Canis familiaris [Reaction:R-RNO-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Rattus norvegicus [Reaction:R-MMU-418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - Mus musculus
output	[DefinedSet:R-HSA-418570] G-protein alpha (12/13):GDP [plasma membrane]
precedingEvent	[Reaction:R-HSA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Homo sapiens [Reaction:R-HSA-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Homo sapiens [Reaction:R-HSA-428918] Dissociation of the TP:G13 complex - Homo sapiens [Reaction:R-HSA-751019] The Ligand:GPCR:G12/13 complex dissociates - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-418574
summation	[Summation:400669] When a ligand activates a G protein-coupled receptor, it ind...
updateTrackers	[UpdateTracker:9790564] Update Tracker - [Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - v33:[modifyText] [UpdateTracker:9781163] Update Tracker - [Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - v61:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790564] Update Tracker - [Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - v33:[modifyText] [UpdateTracker:9781163] Update Tracker - [Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP - v61:[modifyText]
(precedingEvent)	[Reaction:R-HSA-751039] Inactive G alpha (12/13) reassociates with G beta:gamma
(hasEvent)	[Pathway:R-HSA-416482] G alpha (12/13) signalling events

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