G-protein subunits dissociate from WNT:FZD complex

Stable Identifier
R-HSA-3965447
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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After nucleotide exchange, the G-protein alpha subunit dissociates from the beta-gamma complex (reviewed in Malbon, 2004). The G-alpha t2 and o subunits activate signaling through PDEs and promote the release of intracellular calcium (Ahumada et al, 2002; reviewed in Wang and Malbon, 2004) while the beta-gamma complex recruits PLC and initiates phosphoinositol signaling (reviewed in Smrcka, 2008), although both components may also play other roles.

Literature References
PubMed ID Title Journal Year
18488142 G protein betagamma subunits: central mediators of G protein-coupled receptor signaling

Smrcka, AV

Cell Mol Life Sci 2008
12471263 Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Ahumada, A, Slusarski, DC, Liu, X, Moon, RT, Malbon, CC, Wang, HY

Science 2002
14704854 Wnt-frizzled signaling to G-protein-coupled effectors

Wang, H, Malbon, CC

Cell. Mol. Life Sci. 2004
14977528 Frizzleds: new members of the superfamily of G-protein-coupled receptors

Malbon, CC

Front. Biosci. 2004
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