Reactome | G-protein subunits dissociate from WNT:FZD complex

G-protein subunits dissociate from WNT:FZD complex

Stable Identifier

R-HSA-3965447

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane

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G-protein subunits dissociate from WNT:FZD complex

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After nucleotide exchange, the G-protein alpha subunit dissociates from the beta-gamma complex (reviewed in Malbon, 2004). The G-alpha t2 and o subunits activate signaling through PDEs and promote the release of intracellular calcium (Ahumada et al, 2002; reviewed in Wang and Malbon, 2004) while the beta-gamma complex recruits PLC and initiates phosphoinositol signaling (reviewed in Smrcka, 2008), although both components may also play other roles.

Literature References

PubMed ID	Title	Journal	Year
18488142	G protein betagamma subunits: central mediators of G protein-coupled receptor signaling Smrcka, AV	Cell Mol Life Sci	2008
12471263	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP Ahumada, A, Slusarski, DC, Liu, X, Moon, RT, Malbon, CC, Wang, HY	Science	2002
14704854	Wnt-frizzled signaling to G-protein-coupled effectors Wang, H, Malbon, CC	Cell. Mol. Life Sci.	2004
14977528	Frizzleds: new members of the superfamily of G-protein-coupled receptors Malbon, CC	Front. Biosci.	2004