After nucleotide exchange, the G-protein alpha subunit dissociates from the beta-gamma complex (reviewed in Malbon, 2004). The G-alpha t2 and o subunits activate signaling through PDEs and promote the release of intracellular calcium (Ahumada et al, 2002; reviewed in Wang and Malbon, 2004) while the beta-gamma complex recruits PLC and initiates phosphoinositol signaling (reviewed in Smrcka, 2008), although both components may also play other roles.
Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT
Smrcka, AV
Wang, H, Malbon, CC
Malbon, CC
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