Reactome | G-protein subunits dissociate from WNT:FZD complex

G-protein subunits dissociate from WNT:FZD complex

Stable Identifier

R-HSA-3965447

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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G-protein subunits dissociate from WNT:FZD complex

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After nucleotide exchange, the G-protein alpha subunit dissociates from the beta-gamma complex (reviewed in Malbon, 2004). The G-alpha t2 and o subunits activate signaling through PDEs and promote the release of intracellular calcium (Ahumada et al, 2002; reviewed in Wang and Malbon, 2004) while the beta-gamma complex recruits PLC and initiates phosphoinositol signaling (reviewed in Smrcka, 2008), although both components may also play other roles.

Literature References

PubMed ID	Title	Journal	Year
12471263	Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT	Science	2002
18488142	G protein betagamma subunits: central mediators of G protein-coupled receptor signaling Smrcka, AV	Cell Mol Life Sci	2008
14704854	Wnt-frizzled signaling to G-protein-coupled effectors Wang, H, Malbon, CC	Cell. Mol. Life Sci.	2004
14977528	Frizzleds: new members of the superfamily of G-protein-coupled receptors Malbon, CC	Front. Biosci.	2004