WNT:FZD complex promotes G-protein nucleotide exchange

Stable Identifier
R-HSA-3965444
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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WNT:FZD complex promotes G-protein nucleotide exchange
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After binding the FZD receptor, the G-protein alpha subunit exchanges GDP for GTP (reviewed in Malbon, 2004).
Literature References
PubMed ID Title Journal Year
14977528 Frizzleds: new members of the superfamily of G-protein-coupled receptors

Malbon, CC

Front. Biosci. 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane]

Physical Entity
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
WNT:FZD complex promotes G-protein nucleotide exchange (Bos taurus)
WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)
WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)
WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)
WNT:FZD complex promotes G-protein nucleotide exchange (Gallus gallus)
WNT:FZD complex promotes G-protein nucleotide exchange (Mus musculus)
WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)
WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)
WNT:FZD complex promotes G-protein nucleotide exchange (Xenopus tropicalis)
Authored
Rothfels, K  (2013-07-10)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-07-23)
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