Peroxisomal HSD17B4 dimer catalyzes the reaction of trans-2,...

created [InstanceEdit:389984] D'Eustachio, P, 2009-01-21 23:05:37
dbId 389998
displayName Peroxisomal HSD17B4 dimer catalyzes the reaction of trans-2,...
modified [InstanceEdit:9914019] D'Eustachio, Peter, 2024-06-19
schemaClass Summation
text Peroxisomal HSD17B4 dimer catalyzes the reaction of trans-2,3-dehydropristanoyl-CoA and H2O to form 3-hydroxypristanoyl-CoA. The enzyme is bifunctional - an aminoterminal domain catalyzes the dehydrogenation of a variety of 3-hydroxyacyl-CoA's and a carboxyterminal domain catalyzes the hydration of a variety of trans-2,3-dehydroacyl-CoA's, the reaction annotated here (Ferdinandusse et al. 2004; Jiang et al. 1996, 1997). Defects in the enzyme are associated with a severe disorder of peroxisomal fatty acid metabolism in humans (Ferdinandusse et al. 2006).
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