Reactome | ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA

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ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:11009651] pristanoyl-CoA oxidase activity of ACOX2:FAD, ACOXL:FAD [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11009653
displayName	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA
eventOf	[Pathway:R-DDI-389887] Beta-oxidation of pristanoyl-CoA - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-389893] (2S) Pristanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-113535] O2 [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2 (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
output	[SimpleEntity:R-ALL-113575] H2O2 [peroxisomal matrix] [SimpleEntity:R-ALL-389894] trans-2,3-dehydropristanoyl-CoA [peroxisomal matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-389889
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-389887] Beta-oxidation of pristanoyl-CoA
(precedingEvent)	[Reaction:R-DDI-389986] trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
(inferredTo)	[Reaction:R-HSA-389889] ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA

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