Reactome | CD28 homodimer binds B7-1 homodimer

Schema > Reaction > Entries

CD28 homodimer binds B7-1 homodimer Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19 [InstanceEdit:425945] Garapati, P V, 2009-06-09 [InstanceEdit:9928156] Garapati, Phani Vijay, 2024-11-11
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
dbId	388811
displayName	CD28 homodimer binds B7-1 homodimer
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19 [InstanceEdit:9927591] Tiwari, Krishna, 2024-11-08
entityOnOtherCell	[Complex:R-HSA-179787] CD80 dimer [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-389356] Co-stimulation by CD28 - Homo sapiens
followingEvent	[Reaction:R-HSA-388831] Phosphorylation of CD28 - Homo sapiens
input	[Complex:R-HSA-179780] CD28 homodimer [plasma membrane] [Complex:R-HSA-179787] CD80 dimer [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:388687] Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis [LiteratureReference:388646] Interactions of CD80 and CD86 with CD28 and CTLA4
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CD28 homodimer binds B7-1 homodimer
orthologousEvent	[Reaction:R-GGA-388811] CD28 homodimer binds B7-1 homodimer - Gallus gallus [Reaction:R-XTR-388811] CD28 homodimer binds B7-1 homodimer - Xenopus tropicalis [Reaction:R-SSC-388811] CD28 homodimer binds B7-1 homodimer - Sus scrofa [Reaction:R-BTA-388811] CD28 homodimer binds B7-1 homodimer - Bos taurus [Reaction:R-CFA-388811] CD28 homodimer binds B7-1 homodimer - Canis familiaris [Reaction:R-RNO-388811] CD28 homodimer binds B7-1 homodimer - Rattus norvegicus [Reaction:R-MMU-388811] CD28 homodimer binds B7-1 homodimer - Mus musculus
output	[Complex:R-HSA-388767] CD28:B7-1 [plasma membrane]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9927348] Negative regulation by 'PP2A:CTLA4:B7-1/B7-2 [plasma membrane]'
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 [InstanceEdit:9927531] Matthews, Lisa, 2024-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-388811
summation	[Summation:388726] CD28 binding to B7-1 on antigen-presenting cells (APCs) prov...
updateTrackers	[UpdateTracker:9928512] Update Tracker - [Reaction:388811] CD28 homodimer binds B7-1 homodimer - v91:[modifyText, removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9928512] Update Tracker - [Reaction:388811] CD28 homodimer binds B7-1 homodimer - v91:[modifyText, removeRegulator]
(hasEvent)	[Pathway:R-HSA-389356] Co-stimulation by CD28
(precedingEvent)	[Reaction:R-HSA-388831] Phosphorylation of CD28