Reactome | Co-stimulation by CD28

Schema > Pathway > Entries

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049636
displayName	Co-stimulation by CD28
eventOf	[Pathway:R-DDI-388841] Regulation of T cell activation by CD28 family - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:173020] T cell costimulation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DDI-389357] CD28 dependent PI3K/Akt signaling - Dictyostelium discoideum [Pathway:R-DDI-389359] CD28 dependent Vav1 pathway - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-389356] Co-stimulation by CD28 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Co-stimulation by CD28 CD28 co-stimulation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-389356
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-388841] Regulation of T cell activation by CD28 family
(hasEncapsulatedEvent)	[Pathway:R-DDI-389513] Co-inhibition by CTLA4
(inferredTo)	[Pathway:R-HSA-389356] Co-stimulation by CD28

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