Reactome | L-Leu [cytosol]

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L-Leu [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9639290] SESN1,2:L-Leu [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-379974] leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Homo sapiens [Reaction:R-MMU-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Mus musculus [Reaction:R-RNO-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Rattus norvegicus [Reaction:R-CFA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Canis familiaris [Reaction:R-BTA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Bos taurus [Reaction:R-SSC-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Sus scrofa [Reaction:R-DRE-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Danio rerio [Reaction:R-XTR-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Xenopus tropicalis [Reaction:R-GGA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Gallus gallus [Reaction:R-DME-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Drosophila melanogaster [Reaction:R-SCE-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu - Saccharomyces cerevisiae [FailedReaction:R-HSA-5655702] Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu - Homo sapiens [FailedReaction:R-HSA-5660890] Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu - Homo sapiens [BlackBoxEvent:R-DDI-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Dictyostelium discoideum [BlackBoxEvent:R-GGA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Gallus gallus [BlackBoxEvent:R-XTR-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Xenopus tropicalis [BlackBoxEvent:R-DRE-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Danio rerio [BlackBoxEvent:R-SSC-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Sus scrofa [BlackBoxEvent:R-BTA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Bos taurus [BlackBoxEvent:R-CFA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-RNO-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Rattus norvegicus [BlackBoxEvent:R-MMU-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Mus musculus [BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 - Homo sapiens
crossReference	[DatabaseIdentifier:29589] COMPOUND:C00123
dbId	29588
displayName	L-Leu [cytosol]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-508182] Leu, Ile, Val [cytosol] [DefinedSet:R-ALL-352114] ligands of SLC43A1,2 [cytosol] [DefinedSet:R-ALL-352227] ligands of SLC7A5 [cytosol] [DefinedSet:R-ALL-375459] SLC6A14 ligands [cytosol] [DefinedSet:R-ALL-352190] ligands of SLC7A8 [cytosol]
modified	[InstanceEdit:9619952] Wu, G, 2018-09-19
name	L-Leu 2-amino-4-methylvaleric acid L-leucine zwitterion L-leucine (2S)-alpha-2-Amino-4-methylvaleric acid (2S)-alpha-Leucine
producedByEvent	[Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Homo sapiens [Reaction:R-MMU-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Mus musculus [Reaction:R-RNO-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Rattus norvegicus [Reaction:R-CFA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Canis familiaris [Reaction:R-BTA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Bos taurus [Reaction:R-DRE-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Danio rerio [Reaction:R-XTR-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Xenopus tropicalis [Reaction:R-DME-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Drosophila melanogaster [Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Homo sapiens [Reaction:R-MMU-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Mus musculus [Reaction:R-RNO-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Rattus norvegicus [Reaction:R-BTA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Bos taurus [Reaction:R-SSC-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Sus scrofa [Reaction:R-DRE-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Danio rerio [Reaction:R-XTR-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Xenopus tropicalis [Reaction:R-DME-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Drosophila melanogaster
referenceEntity	[ReferenceMolecule:chebi:57427] L-leucine zwitterion [ChEBI:57427]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-29588
updateTrackers	[UpdateTracker:9895730] Update Tracker - [SimpleEntity:29588] L-Leu [cytosol] - v59:[addName, add_removeReferenceEntity] [UpdateTracker:9874324] Update Tracker - [SimpleEntity:29588] L-Leu [cytosol] - v43:[addName] [UpdateTracker:9891032] Update Tracker - [SimpleEntity:29588] L-Leu [cytosol] - v52:[modifyName]

Referrals

(hasComponent)	[Complex:R-HSA-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-CFA-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-SSC-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-MMU-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-DRE-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-GGA-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-XTR-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-RNO-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-BTA-9639290] SESN1,2:L-Leu [cytosol] [Complex:R-DDI-9639290] SESN1,2:L-Leu [cytosol]
(input)	[Reaction:R-HSA-379974] leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate [FailedReaction:R-HSA-5655702] Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu [FailedReaction:R-HSA-5660890] Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu [BlackBoxEvent:R-DDI-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-GGA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-XTR-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-DRE-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-SSC-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-BTA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-CFA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-RNO-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [BlackBoxEvent:R-MMU-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2 [Reaction:R-HSA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-MMU-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-RNO-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-CFA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-BTA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-SSC-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-DRE-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-XTR-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-GGA-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-DME-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [Reaction:R-SCE-379432] SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu [BlackBoxEvent:R-HSA-9639287] SESN1,2 binds L-leucine and dissociates from GATOR2
(output)	[Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-MMU-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-RNO-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-CFA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-BTA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-DRE-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-XTR-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-DME-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-MMU-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-RNO-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-BTA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-SSC-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-DRE-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-XTR-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-DME-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
(hasMember)	[DefinedSet:R-ALL-508182] Leu, Ile, Val [cytosol] [DefinedSet:R-ALL-352227] ligands of SLC7A5 [cytosol] [DefinedSet:R-ALL-375459] SLC6A14 ligands [cytosol] [DefinedSet:R-ALL-352088] ligands of SLC38A2 [cytosol] [DefinedSet:R-ALL-352114] ligands of SLC43A1,2 [cytosol] [DefinedSet:R-ALL-352048] ligands of SLC6A15 [cytosol] [DefinedSet:R-ALL-352190] ligands of SLC7A8 [cytosol] [DefinedSet:R-ALL-375481] neutral amino acids [cytosol]
(updatedInstance)	[UpdateTracker:9895730] Update Tracker - [SimpleEntity:29588] L-Leu [cytosol] - v59:[addName, add_removeReferenceEntity] [UpdateTracker:9874324] Update Tracker - [SimpleEntity:29588] L-Leu [cytosol] - v43:[addName] [UpdateTracker:9891032] Update Tracker - [SimpleEntity:29588] L-Leu [cytosol] - v52:[modifyName]

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