G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.
Dowal, L, Provitera, P, Scarlata, S
Amatruda TT, 3rd, Steele, DA, Slepak, VZ, Simon, MI
Ferguson, KM, Higashijima, T, Smigel, MD, Gilman, AG
Chen, B, Leverette, RD, Schwinn, DA, Kwatra, MM
Rubio, JP, Levy, ER, Dobson-Stone, C, Monaco, AP
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