Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Stable Identifier
R-HSA-379048
Type
Reaction
Species
Homo sapiens
Compartment
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G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.

Literature References
PubMed ID Title Journal Year
1905813 G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells

Slepak, VZ, Simon, MI, Amatruda TT, 3rd, Steele, DA

Proc Natl Acad Sci U S A 1991
16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells

Scarlata, S, Provitera, P, Dowal, L

J Biol Chem 2006
3086311 The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins

Ferguson, KM, Gilman, AG, Smigel, MD, Higashijima, T

J Biol Chem 1986
8664309 Human G(alpha q): cDNA and tissue distribution

Kwatra, MM, Leverette, RD, Chen, B, Schwinn, DA

Biochim Biophys Acta 1996
10191087 Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC)

Monaco, AP, Levy, ER, Rubio, JP, Dobson-Stone, C

Genomics 1999
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of LTC4:CyslTR1,2 [plasma membrane]

Orthologous Events
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