G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.
Slepak, VZ, Simon, MI, Amatruda TT, 3rd, Steele, DA
Scarlata, S, Provitera, P, Dowal, L
Ferguson, KM, Gilman, AG, Smigel, MD, Higashijima, T
Kwatra, MM, Leverette, RD, Chen, B, Schwinn, DA
Monaco, AP, Levy, ER, Rubio, JP, Dobson-Stone, C
guanyl-nucleotide exchange factor activity of LTC4:CyslTR1,2 [plasma membrane]
© 2022 Reactome
