Reactome | Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Stable Identifier

R-HSA-379048

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

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G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.

Literature References

PubMed ID	Title	Journal	Year
1905813	G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells Slepak, VZ, Simon, MI, Amatruda TT, 3rd, Steele, DA	Proc Natl Acad Sci U S A	1991
16754659	Stable association between G alpha(q) and phospholipase C beta 1 in living cells Scarlata, S, Provitera, P, Dowal, L	J Biol Chem	2006
3086311	The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins Ferguson, KM, Gilman, AG, Smigel, MD, Higashijima, T	J Biol Chem	1986
8664309	Human G(alpha q): cDNA and tissue distribution Kwatra, MM, Leverette, RD, Chen, B, Schwinn, DA	Biochim Biophys Acta	1996
10191087	Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC) Monaco, AP, Levy, ER, Rubio, JP, Dobson-Stone, C	Genomics	1999