Reactome | Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Schema > Reaction > Entries

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 Show undefined attributes

catalystActivity	[CatalystActivity:10011103] guanyl-nucleotide exchange factor activity of LTC4:CyslTR1,2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10011105
displayName	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
eventOf	[Pathway:R-MMU-416476] G alpha (q) signalling events - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-749452] The Ligand:GPCR:Gq complex dissociates - Mus musculus
inferredFrom	[Reaction:R-HSA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-749451] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-749447] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane]
precedingEvent	[Reaction:R-MMU-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-379048
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-416476] G alpha (q) signalling events
(precedingEvent)	[Reaction:R-MMU-749452] The Ligand:GPCR:Gq complex dissociates
(inferredTo)	[Reaction:R-HSA-379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

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