Reactome | Signaling by ROBO receptors

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Signaling by ROBO receptors Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826865
displayName	Signaling by ROBO receptors
eventOf	[Pathway:R-GGA-422475] Axon guidance - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-GGA-9010553] Regulation of expression of SLITs and ROBOs - Gallus gallus [Reaction:R-GGA-428518] Glypican-1 (GPC1) binds SLIT2 - Gallus gallus [Reaction:R-GGA-9010815] SLITs bind keratan sulfate - Gallus gallus [Reaction:R-GGA-9014812] ROBOs bind keratan sulfate - Gallus gallus [Pathway:R-GGA-8985586] SLIT2:ROBO1 increases RHOA activity - Gallus gallus
inferredFrom	[Pathway:R-HSA-376176] Signaling by ROBO receptors - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by ROBO receptors
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-376176
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-422475] Axon guidance
(inferredTo)	[Pathway:R-HSA-376176] Signaling by ROBO receptors

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