Reactome | Role of ABL in ROBO-SLIT signaling

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Role of ABL in ROBO-SLIT signaling Show undefined attributes

authored	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:428889] Garapati, P V, 2009-07-10
dbId	428890
displayName	Role of ABL in ROBO-SLIT signaling
edited	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05 [InstanceEdit:9010186] Orlic-Milacic, Marija, 2017-06-26
eventOf	[Pathway:R-HSA-376176] Signaling by ROBO receptors - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-376141] Interaction of ABL with ROBO1:SLIT2 - Homo sapiens [Reaction:R-HSA-428888] Phosphorylation of ROBO1 by ABL kinase - Homo sapiens [Reaction:R-HSA-428885] Activation of CLASP - Homo sapiens [Reaction:R-HSA-428883] Recruitment of CAP to ABL - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:428835] A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding [LiteratureReference:428841] Hot +TIPS: guidance cues signal directly to microtubules [LiteratureReference:428842] The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Role of ABL in ROBO-SLIT signaling
orthologousEvent	[Pathway:R-DME-428890] Role of ABL in ROBO-SLIT signaling - Drosophila melanogaster [Pathway:R-BTA-428890] Role of ABL in ROBO-SLIT signaling - Bos taurus [Pathway:R-MMU-428890] Role of ABL in ROBO-SLIT signaling - Mus musculus
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434966] Kidd, T, 2009-08-18 [InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-428890
summation	[Summation:428844] ABL (ABL1 or ABL2) plays a dual role in the ROBO pathway. As...
updateTrackers	[UpdateTracker:9789116] Update Tracker - [Pathway:428890] Role of ABL in ROBO-SLIT signaling - v38:[addLiteratureReference] [UpdateTracker:9780653] Update Tracker - [Pathway:428890] Role of ABL in ROBO-SLIT signaling - v62:[modifyText, updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9789116] Update Tracker - [Pathway:428890] Role of ABL in ROBO-SLIT signaling - v38:[addLiteratureReference] [UpdateTracker:9780653] Update Tracker - [Pathway:428890] Role of ABL in ROBO-SLIT signaling - v62:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-376176] Signaling by ROBO receptors