Receptors CXCR4 and 7 bind CXCL12 ligand

Stable Identifier
R-HSA-374214
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et al, 1995) is produced in two forms, CXCL12alpha and CXCL12beta, by alternate splicing of the same gene (De La Luz Sierra M et al, 2004). It is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. In adult humans it plays an important role in angiogenesis by recruiting endothelial progenitor cells from the bone morrow through a CXCR4-dependent mechanism. CXCR4 (fusin) (Herzog H et al, 1993) is the receptor for CXCL12 and, like CCR5, is utilized by HIV-1 to gain entry into target cells. This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types and also on vascular endothelial cells and neuronal/nerve cells. CXCR7 (RDC-1) (Infantino S et al, 2006) is expressed in monocytes, basophils and B cells and was originally an orphan receptor.

Literature References
PubMed ID Title Journal Year
9618518 Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor

Dealwis, C, Fernandez, EJ, Thompson, DA, Simon, RJ, Siani, MA, Lolis, E

Proc Natl Acad Sci U S A 1998
16107333 The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes

Balabanian, K, Lagane, B, Infantino, S, Chow, KY, Harriague, J, Moepps, B, Arenzana-Seisdedos, F, Thelen, M, Bachelerie, F

J Biol Chem 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created