Reactome | Receptors CXCR4 and 7 bind CXCL12 ligand

Receptors CXCR4 and 7 bind CXCL12 ligand

Stable Identifier

R-HSA-374214

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)

General

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Receptors CXCR4 and 7 bind CXCL12 ligand

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CXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et al, 1995) is produced in two forms, CXCL12alpha and CXCL12beta, by alternate splicing of the same gene (De La Luz Sierra M et al, 2004). It is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. In adult humans it plays an important role in angiogenesis by recruiting endothelial progenitor cells from the bone morrow through a CXCR4-dependent mechanism. CXCR4 (fusin) (Herzog H et al, 1993) is the receptor for CXCL12 and, like CCR5, is utilized by HIV-1 to gain entry into target cells. This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types and also on vascular endothelial cells and neuronal/nerve cells. CXCR7 (RDC-1) (Infantino S et al, 2006) is expressed in monocytes, basophils and B cells and was originally an orphan receptor.

Literature References

PubMed ID	Title	Journal	Year
16107333	The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes Balabanian, K, Lagane, B, Infantino, S, Chow, KY, Harriague, J, Moepps, B, Arenzana-Seisdedos, F, Thelen, M, Bachelerie, F	J Biol Chem	2005
9618518	Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor Dealwis, C, Fernandez, EJ, Thompson, DA, Simon, RJ, Siani, MA, Lolis, E	Proc Natl Acad Sci U S A	1998