Reactome | Receptors CXCR4 and 7 bind CXCL12 ligand

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Receptors CXCR4 and 7 bind CXCL12 ligand Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10752592
displayName	Receptors CXCR4 and 7 bind CXCL12 ligand
eventOf	[Pathway:R-GGA-380108] Chemokine receptors bind chemokines - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Gallus gallus
inferredFrom	[Reaction:R-HSA-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-2980693] CXCL12 [extracellular region] [EntityWithAccessionedSequence:R-GGA-2980772] CXCR4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Receptors CXCR4 and 7 bind CXCL12 ligand
output	[Complex:R-GGA-374203] CXCR4,7:CXCL12 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-374214
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-380108] Chemokine receptors bind chemokines
(precedingEvent)	[Reaction:R-GGA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
(inferredTo)	[Reaction:R-HSA-374214] Receptors CXCR4 and 7 bind CXCL12 ligand

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