Reactome | ERBB2 [plasma membrane]

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ERBB2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-1227936] ERBB2 homodimer [plasma membrane] - Homo sapiens [Complex:R-HSA-1227936] ERBB2 homodimer [plasma membrane] - Homo sapiens [Complex:R-HSA-419627] ERBB2:p-Y-PLXNB1 [plasma membrane] - Homo sapiens
created	[InstanceEdit:372890] Gopinathrao, G, 2008-07-08 21:55:28
dbId	372889
displayName	ERBB2 [plasma membrane]
endCoordinate	1255
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-372889] ERBB2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-RNO-372889] ERBB2 [plasma membrane] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-372889] ERBB2 [plasma membrane] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-372889] ERBB2 [plasma membrane] - Bos taurus [EntityWithAccessionedSequence:R-SSC-372889] ERBB2 [plasma membrane] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-372889] ERBB2 [plasma membrane] - Danio rerio [GenomeEncodedEntity:R-XTR-372889] Ghost homologue of ERBB2 [plasma membrane] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-372889] ERBB2 [plasma membrane] - Gallus gallus [EntityWithAccessionedSequence:R-DME-372889] ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-372889] ERBB2 [plasma membrane] - Caenorhabditis elegans [GenomeEncodedEntity:R-SPO-372889] Ghost homologue of ERBB2 [plasma membrane] - Schizosaccharomyces pombe
markingReferences	[MarkerReference:9941930] ERBB2 [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue
maxDepth	1
modified	[InstanceEdit:3322334] Wu, G, 2013-05-03
name	ERBB2 ErbB2
producedByEvent	[BlackBoxEvent:R-HSA-8864466] TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-372889
startCoordinate	23
updateTrackers	[UpdateTracker:9870058] Update Tracker - [EntityWithAccessionedSequence:372889] ERBB2 [plasma membrane] - v37:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9880802] Update Tracker - [EntityWithAccessionedSequence:372889] ERBB2 [plasma membrane] - v45:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9870058] Update Tracker - [EntityWithAccessionedSequence:372889] ERBB2 [plasma membrane] - v37:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9880802] Update Tracker - [EntityWithAccessionedSequence:372889] ERBB2 [plasma membrane] - v45:[addName]
(hasComponent)	[Complex:R-HSA-1227936] ERBB2 homodimer [plasma membrane] [Complex:R-HSA-419627] ERBB2:p-Y-PLXNB1 [plasma membrane] [Complex:R-HSA-419629] Plexin-B1:ErbB2 [plasma membrane] [Complex:R-HSA-1918081] Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Complex:R-HSA-1918083] Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] [Complex:R-HSA-9652356] ERBB2:TKIs [plasma membrane] [Complex:R-HSA-9665221] ERBB2:trastuzumab [plasma membrane] [Complex:R-HSA-9665975] ERBB2:pertuzumab [plasma membrane] [Complex:R-HSA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Complex:R-HSA-1247502] NRG1/2:ERBB3:ERBB2 [plasma membrane] [Complex:R-HSA-1250312] ERBB2:ERBB4cyt2 heterodimer [plasma membrane] [Complex:R-HSA-1250328] ERBB2:ERBB4cyt1 heterodimers [plasma membrane] [Complex:R-HSA-1227939] EGF:EGFR:ERBB2 [plasma membrane]
(proteinMarker)	[Cell:R-HSA-9925889] mammary stem cell
(marker)	[MarkerReference:9941930] ERBB2 [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue
(output)	[BlackBoxEvent:R-HSA-8864466] TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
(activeUnit)	[CatalystActivity:419656] protein tyrosine kinase activity of Plexin-B1:ErbB2 [plasma membrane]

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