BAX is a member of the group of pro-apoptotic proteins possessing the BH3 domain. These proteins undergo conformational activation leading to oligomerization and insertion in the outer mitochondrial membrane. This process is presumed to result in permeabilization of outer mitochondrial membrane and egress of apoptogenic factors, such as cytochrome C, that activate the caspase cascade leading to cellular demise. BAX gene transcription is stimulated by binding of TP53 (p53) (Miyashita and Reed 1995) or p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004) to the p53 response element in the BAX gene promoter. ASSP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members and enhance transcription of the BAX gene (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).
Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X
Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X
Miyashita, T, Reed, JC
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