TP53 family members stimulate BAX transcription

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
BAX is a member of the group of pro-apoptotic proteins possessing the BH3 domain. These proteins undergo conformational activation leading to oligomerization and insertion in the outer mitochondrial membrane. This process is presumed to result in permeabilization of outer mitochondrial membrane and egress of apoptogenic factors, such as cytochrome C, that activate the caspase cascade leading to cellular demise. BAX gene transcription is stimulated by binding of TP53 (p53) (Miyashita and Reed 1995) or p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004) to the p53 response element in the BAX gene promoter. ASSP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members and enhance transcription of the BAX gene (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).
Literature References
PubMed ID Title Journal Year
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Hsieh, JK, Trigiante, G, Crook, T, Zhong, S, Bergamaschi, D, O'Connor, DJ, Lu, X, Campargue, I, Naumovski, L, Samuels-Lev, Y

Mol. Cell 2001
14729977 ASPP1 and ASPP2: common activators of p53 family members

Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T

Mol. Cell. Biol. 2004
7834749 Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Miyashita, T, Reed, JC

Cell 1995
This event is regulated
Cite Us!