SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

Stable Identifier
R-HSA-352232
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SLC7A5-mediated uptake of neutral amino acids
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SLC7A5, complexed with SLC3A2 in the plasma membrane, mediates the uptake of neutral amino acids. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC7A5 is widely expressed in the body. In situ hybridization studies indicate that the gene product is widely expressed in the body but not in the kidney (Pineda et al. 1999; Prasad et al. 1999).

Literature References
PubMed ID Title Journal Year
10049700 Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function

Prasad, PD, Wang, H, Huang, W, Kekuda, R, Rajan, DP, Leibach, FH, Ganapathy, V

Biochem Biophys Res Commun 1999
10391915 Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids

Pineda, M, Fernández, E, Torrents, D, Estévez, R, López, C, Camps, M, Lloberas, J, Zorzano, A, Palacin, M

J Biol Chem 1999
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
amino acid transmembrane transporter activity of SLC7A5:SLC3A2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created