SLC7A5, complexed with SLC3A2 in the plasma membrane, mediates the uptake of neutral amino acids. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC7A5 is widely expressed in the body. In situ hybridization studies indicate that the gene product is widely expressed in the body but not in the kidney (Pineda et al. 1999; Prasad et al. 1999).
Palacin, M, Torrents, D, Zorzano, A, Lloberas, J, López, C, Fernández, E, Pineda, M, Camps, M, Estévez, R
Leibach, FH, Ganapathy, V, Huang, W, Rajan, DP, Prasad, PD, Kekuda, R, Wang, H
amino acid transmembrane transporter activity of SLC7A5:SLC3A2 [plasma membrane]
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