Reactome | SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

Stable Identifier

R-HSA-352232

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

L-leucine(in) = L-leucine(out), L-valine(in) = L-valine(out), L-tyrosine(in) = L-tyrosine(out), L-histidine(in) = L-histidine(out), L-tryptophan(in) = L-tryptophan(out), L-phenylalanine(in) = L-phenylalanine(out), L-methionine(in) = L-methionine(out), L-isoleucine(in) = L-isoleucine(out), L-alanine(in) = L-alanine(out)

ReviewStatus

5/5

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SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

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SLC7A5, complexed with SLC3A2 in the plasma membrane, mediates the uptake of neutral amino acids. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC7A5 is widely expressed in the body. In situ hybridization studies indicate that the gene product is widely expressed in the body but not in the kidney (Pineda et al. 1999; Prasad et al. 1999, Vumma et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
10049700	Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function Prasad, PD, Wang, H, Huang, W, Kekuda, R, Rajan, DP, Leibach, FH, Ganapathy, V	Biochem Biophys Res Commun	1999
18262359	Functional characterization of tyrosine transport in fibroblast cells from healthy controls Vumma, R, Wiesel, FA, Flyckt, L, Bjerkenstedt, L, Venizelos, N	Neurosci Lett	2008
10391915	Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids Pineda, M, Fernández, E, Torrents, D, Estévez, R, López, C, Camps, M, Lloberas, J, Zorzano, A, Palacin, M	J Biol Chem	1999