Reactome | SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

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SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10356089] L-amino acid transmembrane transporter activity of SLC7A5:SLC3A2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10356091
displayName	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
eventOf	[Pathway:R-BTA-71240] Tryptophan catabolism - Bos taurus [Pathway:R-BTA-352230] Amino acid transport across the plasma membrane - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-888614] IDO2 dioxygenates L-Trp to NFK - Bos taurus [Reaction:R-BTA-71188] TDO tetramer dioxygenates L-Trp to NFK - Bos taurus [Reaction:R-BTA-198563] IDO1 dioxygenates L-Trp to NFK - Bos taurus
goBiologicalProcess	[GO_BiologicalProcess:5083556] L-alpha-amino acid transmembrane transport
inferredFrom	[Reaction:R-HSA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Homo sapiens
input	[DefinedSet:R-ALL-352229] ligands of SLC7A5 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol L-leucine(in) = L-leucine(out) L-valine(in) = L-valine(out) L-tyrosine(in) = L-tyrosine(out) L-histidine(in) = L-histidine(out) L-tryptophan(in) = L-tryptophan(out) L-phenylalanine(in) = L-phenylalanine(out) L-methionine(in) = L-methionine(out) L-isoleucine(in) = L-isoleucine(out) L-alanine(in) = L-alanine(out)
output	[DefinedSet:R-ALL-352227] ligands of SLC7A5 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-352232
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-352230] Amino acid transport across the plasma membrane [Pathway:R-BTA-71240] Tryptophan catabolism
(precedingEvent)	[Reaction:R-BTA-888614] IDO2 dioxygenates L-Trp to NFK [Reaction:R-BTA-71188] TDO tetramer dioxygenates L-Trp to NFK [Reaction:R-BTA-198563] IDO1 dioxygenates L-Trp to NFK
(inferredTo)	[Reaction:R-HSA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

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