SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine

Stable Identifier
R-HSA-352182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC38A5 (SN2), associated with the plasma membrane, mediates the uptake of asparagine, glutamine, histidine, serine and, with lower efficiency, alanine and glycine. Indirect assays suggest that amino acid uptake is coupled to the uptake of sodium ion(s) and the export of H+. Northern blotting experiments indicate gene expression in brain and stomach, and at lower levels in liver, lung, and intestine (Nakanishi et al. 2001).

Literature References
PubMed ID Title Journal Year
11243884 Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N

Nakanishi, T, Sugawara, M, Huang, W, Martindale, RG, Leibach, FH, Ganapathy, ME, Prasad, PD, Ganapathy, V

Biochem Biophys Res Commun 2001
Participants
Participates
Catalyst Activity

amino acid transmembrane transporter activity of SLC38A5 [plasma membrane]

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