Reactome | dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

Schema > Reaction > Entries

dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine Show undefined attributes

catalystActivity	[CatalystActivity:10578599] spermine synthase activity of SMS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578601
displayName	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine
eventOf	[Pathway:R-DRE-351202] Metabolism of polyamines - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-351207] Spermine => N-acetylated spermine - Danio rerio [Reaction:R-DRE-1237160] MTA is cleaved and phosphorylated - Danio rerio
inferredFrom	[Reaction:R-HSA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine - Homo sapiens
input	[SimpleEntity:R-ALL-353113] dc-AdoMet [cytosol] [SimpleEntity:R-ALL-204635] SPM [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => spermine + S-methyl-5'-thioadenosine + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-353106] MTAD [cytosol] [SimpleEntity:R-ALL-353560] SPN [cytosol]
precedingEvent	[Reaction:R-DRE-351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - Danio rerio [Reaction:R-DRE-351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-351210
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-351202] Metabolism of polyamines
(precedingEvent)	[Reaction:R-DRE-351207] Spermine => N-acetylated spermine [Reaction:R-DRE-1237160] MTA is cleaved and phosphorylated
(inferredTo)	[Reaction:R-HSA-351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

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