Reactome | dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

Stable Identifier

R-HSA-351210

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => spermine + S-methyl-5'-thioadenosine + H(+)

ReviewStatus

5/5

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dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

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Spermine synthase (SMS), a member of the spermidine/spermine synthases family, is a ubiquitous enzyme of polyamine metabolism. Here, it transfers an aminopropyl group from decarboxylated S-adenosylmethionine (dc-AdoMet) to spermidine (SPM) to form spermine (SPN) (Korhonen et al. 1995; Wu et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
7546290	Molecular cloning of a cDNA encoding human spermine synthase Korhonen, VP, Halmekytö, M, Kauppinen, L, Myöhänen, S, Wahlfors, J, Keinänen, T, Hyvönen, T, Alhonen, L, Eloranta, T, Jänne, J	DNA Cell Biol	1995
18367445	Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism Wu, H, Min, J, Zeng, H, McCloskey, DE, Ikeguchi, Y, Loppnau, P, Michael, AJ, Pegg, AE, Plotnikov, AN	J Biol Chem	2008