Reactome | CUBN binds GC:25(OH)D

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CUBN binds GC:25(OH)D Show undefined attributes

catalystActivity	[CatalystActivity:10129550] cargo receptor activity of CUBN [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10129552
displayName	CUBN binds GC:25(OH)D
eventOf	[Pathway:R-RNO-196791] Vitamin D (calciferol) metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-350186] CUBN binds GC:25(OH)D - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-264843] CUBN [plasma membrane] [Complex:R-RNO-209892] GC:25(OH)D [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	CUBN binds GC:25(OH)D DBP:Calcidiol is sequestered by cubilin on the cell surface
output	[Complex:R-RNO-350115] CUBN:GC:25(OH)D [plasma membrane]
precedingEvent	[Reaction:R-RNO-209944] 25(OH)D binds GC - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-350186
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-196791] Vitamin D (calciferol) metabolism
(precedingEvent)	[Reaction:R-RNO-350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
(inferredTo)	[Reaction:R-HSA-350186] CUBN binds GC:25(OH)D

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