Reactome | CUBN binds GC:25(OH)D

CUBN binds GC:25(OH)D

Stable Identifier

R-HSA-350186

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

DBP:Calcidiol is sequestered by cubilin on the cell surface

ReviewStatus

5/5

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Cubilin (CUBN) is a membrane-associated protein colocalising with megalin (LRP2). Its function is to sequester steroid carrier complexes such as vitamin D binding protein:25-hydroxyvitamin D (GC:25(OH)D) on the cell surface before LRP2 mediates their internalisation (Nykjaer et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11717447	Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3) Fyfe, JC, Gliemann, J, Jacobsen, C, Leheste, JR, Nielsen, MS, Willnow, TE, Ray, R, Kozyraki, R, Moestrup, SK, de la Chapelle, A, Aminoff, M, Nykjaer, A, Christensen, EI, Verroust, PJ	Proc Natl Acad Sci U S A	2001