CUBN binds GC:25(OH)D

Stable Identifier
R-HSA-350186
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
DBP:Calcidiol is sequestered by cubilin on the cell surface
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Cubilin (CUBN) is a membrane-associated protein colocalising with megalin (LRP2). Its function is to sequester steroid carrier complexes such as vitamin D binding protein:25-hydroxyvitamin D (GC:25(OH)D) on the cell surface before LRP2 mediates their internalisation (Nykjaer et al. 2001).

Literature References
PubMed ID Title Journal Year
11717447 Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

Nykjaer, A, Fyfe, JC, Kozyraki, R, Leheste, JR, Jacobsen, C, Nielsen, MS, Verroust, PJ, Aminoff, M, de la Chapelle, A, Moestrup, SK, Ray, R, Gliemann, J, Willnow, TE, Christensen, EI

Proc Natl Acad Sci U S A 2001
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