Reactome | Phosphorylation of MDM4 by ATM

Schema > Reaction > Entries

Phosphorylation of MDM4 by ATM Show undefined attributes

catalystActivity	[CatalystActivity:10578457] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578465
displayName	Phosphorylation of MDM4 by ATM
eventOf	[Pathway:R-DRE-69541] Stabilization of p53 - Danio rerio [Pathway:R-DRE-6804757] Regulation of TP53 Degradation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-349455] Phosphorylation of MDM4 by ATM - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DRE-6804932] p-S166,S188-MDM2:MDM4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of MDM4 by ATM
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-DRE-6804939] p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm]
precedingEvent	[Reaction:R-DRE-6804741] MDM2 forms homo- or heterodimers - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-349455
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-69541] Stabilization of p53 [Pathway:R-DRE-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-349455] Phosphorylation of MDM4 by ATM