PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

Stable Identifier
Reaction [transition]
Homo sapiens
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Peroxiredoxin 1 (PRDX1), PRDX2, and PRDX5 in the cytosol reduce hydrogen peroxide (H2O2) with thioredoxin yielding oxidized thioredoxin and water (Yamashita et al. 1999, Lee et al. 2007, Nagy et al. 2011).

Literature References
PubMed ID Title Journal Year
21385867 Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study

Radom, L, Hampton, MB, O'Reilly, RJ, Karton, A, Nagy, P, Pace, P, Peskin, AV, Betz, A, Winterbourn, CC

J. Biol. Chem. 2011
10514471 Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro

Subramani, S, London, R, Avraham, S, Rogers, RA, Van Veldhoven, PP, Avraham, H, Yamashita, H, Jiang, S

J. Biol. Chem. 1999
17519234 Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2

Riddell, J, Park, JH, Park, YM, Ip, C, Lee, W, Ghosh, D, Choi, KS

J. Biol. Chem. 2007
Catalyst Activity

thioredoxin peroxidase activity of PRDX1,2,5 [cytosol]

Orthologous Events
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