Reactome | PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

Stable Identifier

R-HSA-3341343

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

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Peroxiredoxin 1 (PRDX1), PRDX2, and PRDX5 in the cytosol reduce hydrogen peroxide (H2O2) with thioredoxin yielding oxidized thioredoxin and water (Yamashita et al. 1999, Lee et al. 2007, Nagy et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21385867	Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study Nagy, P, Karton, A, Betz, A, Peskin, AV, Pace, P, O'Reilly, RJ, Hampton, MB, Radom, L, Winterbourn, CC	J. Biol. Chem.	2011
10514471	Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro Yamashita, H, Avraham, S, Jiang, S, London, R, Van Veldhoven, PP, Subramani, S, Rogers, RA, Avraham, H	J. Biol. Chem.	1999
17519234	Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2 Lee, W, Choi, KS, Riddell, J, Ip, C, Ghosh, D, Park, JH, Park, YM	J. Biol. Chem.	2007