Reactome | SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)

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SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) Show undefined attributes

authored	[InstanceEdit:3299684] May, B, 2013-04-20
catalystActivity	[CatalystActivity:3299693] superoxide dismutase activity of 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3299677] May, B, 2013-04-20
crossReference	[DatabaseIdentifier:12667683] RHEA:20697
dbId	3299691
displayName	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
edited	[InstanceEdit:3299684] May, B, 2013-04-20
eventOf	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
followingEvent	[Reaction:R-HSA-3343700] PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens [Reaction:R-HSA-3341277] GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens [Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Homo sapiens [Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Homo sapiens [Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens
input	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-1222424] O2.- [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3299782] High-level expression of enzymatically active human Cu/Zn superoxide dismutase in Escherichia coli [LiteratureReference:3299845] Purification of superoxide dismutases from human placenta using immunoadsorbent columns [LiteratureReference:3299823] Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) [LiteratureReference:3697046] Does cellular hydrogen peroxide diffuse or act locally?
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
orthologousEvent	[Reaction:R-DRE-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Danio rerio [Reaction:R-SCE-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Saccharomyces cerevisiae [Reaction:R-SPO-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Schizosaccharomyces pombe [Reaction:R-DDI-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Dictyostelium discoideum [Reaction:R-CEL-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Caenorhabditis elegans [Reaction:R-DME-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Drosophila melanogaster [Reaction:R-GGA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Gallus gallus [Reaction:R-XTR-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Xenopus tropicalis [Reaction:R-SSC-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Sus scrofa [Reaction:R-BTA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Bos taurus [Reaction:R-CFA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Canis familiaris [Reaction:R-RNO-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Rattus norvegicus [Reaction:R-MMU-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Mus musculus
output	[SimpleEntity:R-ALL-29408] H2O2 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
precedingEvent	[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3299691
summation	[Summation:3299768] Cu-Zn superoxide dismutase (SOD1), originally known as eryth...

Referrals

(precedingEvent)

[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
[Reaction:R-HSA-3343700] PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
[Reaction:R-HSA-3341277] GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate
[Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

(hasEvent)

[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species

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