Reactome | XIAP binds TLE

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XIAP binds TLE Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10170685
displayName	XIAP binds TLE
eventOf	[Pathway:R-RNO-3769402] Deactivation of the beta-catenin transactivating complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3322429] XIAP monoubiquinates TLE - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3322431] XIAP binds TLE - Homo sapiens
input	[DefinedSet:R-RNO-3299565] TLE tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-3322366] XIAP [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	XIAP binds TLE
output	[Complex:R-RNO-3322390] TLE:XIAP [nucleoplasm]
precedingEvent	[Reaction:R-RNO-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3322431
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3769402] Deactivation of the beta-catenin transactivating complex
(precedingEvent)	[Reaction:R-RNO-3322429] XIAP monoubiquinates TLE
(inferredTo)	[Reaction:R-HSA-3322431] XIAP binds TLE