Reactome | SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)

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SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) Show undefined attributes

catalystActivity	[CatalystActivity:10960615] superoxide dismutase activity of 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10960617
displayName	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
eventOf	[Pathway:R-CEL-3299685] Detoxification of Reactive Oxygen Species - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-3343700] PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Caenorhabditis elegans [Reaction:R-CEL-3341277] GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Caenorhabditis elegans [Reaction:R-CEL-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Caenorhabditis elegans [Reaction:R-CEL-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-1222424] O2.- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
output	[SimpleEntity:R-ALL-29408] H2O2 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3299691
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)	[Reaction:R-CEL-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O [Reaction:R-CEL-3343700] PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O [Reaction:R-CEL-3341277] GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O [Reaction:R-CEL-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
(inferredTo)	[Reaction:R-HSA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)