SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)

Stable Identifier
Homo sapiens
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Cu-Zn superoxide dismutase (SOD1), originally known as erythrocuprein, catalyzes the reaction of two molecules of superoxide (O2.-) to yield one molecule of hydrogen peroxide (H2O2) and one molecule of oxygen (O2) (McCord and Fridovich 1969 assayed both bovine and human Cu-Zn superoxide dismutase, the human sample provided by Carrico and Deutsch). Diffusion of hydrogen peroxide, the product of SOD1, across the cytosol is limited (Mishina et al. 2011)

Literature References
PubMed ID Title Journal Year
20690882 Does cellular hydrogen peroxide diffuse or act locally?

Markvicheva, KN, Lukyanov, S, Tyurin-Kuzmin, PA, Vorotnikov, AV, Schultz, C, Tkachuk, VA, Belousov, VV, Laketa, V, Mishina, NM

Antioxid. Redox Signal. 2011
5389100 Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)

Fridovich, I, McCord, JM

J. Biol. Chem. 1969
7021796 Purification of superoxide dismutases from human placenta using immunoadsorbent columns

Hirano, K, Inoue, H, Ito, Y, Adachi, T, Sugiura, M

J. Pharmacobio-dyn. 1981
3532102 High-level expression of enzymatically active human Cu/Zn superoxide dismutase in Escherichia coli

Yavin, Z, Gorecki, M, Bartfeld, D, Aviv, H, Kanner, D, Hartman, JR, Geller, T

Proc. Natl. Acad. Sci. U.S.A. 1986
Catalyst Activity

superoxide dismutase activity of 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol]

Orthologous Events
Cross References
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