Cu-Zn superoxide dismutase (SOD1), originally known as erythrocuprein, catalyzes the reaction of two molecules of superoxide (O2.-) to yield one molecule of hydrogen peroxide (H2O2) and one molecule of oxygen (O2) (McCord and Fridovich 1969 assayed both bovine and human Cu-Zn superoxide dismutase, the human sample provided by Carrico and Deutsch). Diffusion of hydrogen peroxide, the product of SOD1, across the cytosol is limited (Mishina et al. 2011)
Markvicheva, KN, Lukyanov, S, Tyurin-Kuzmin, PA, Vorotnikov, AV, Schultz, C, Tkachuk, VA, Belousov, VV, Laketa, V, Mishina, NM
Fridovich, I, McCord, JM
Hirano, K, Inoue, H, Ito, Y, Adachi, T, Sugiura, M
Yavin, Z, Gorecki, M, Bartfeld, D, Aviv, H, Kanner, D, Hartman, JR, Geller, T
superoxide dismutase activity of 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol]
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